Research progress of postoperative cognitive dysfunction in cardiac surgery under cardiopulmonary bypass

Abstract Cardiopulmonary bypass (CPB) is often used in cardiothoracic surgery because its nonphysiological state causes pathophysiological changes the body, causing multiorgan and multitissue damage to varying degrees. Postoperative cognitive dysfunction (POCD) a common central nervous system complication after cardiac surgery. The etiology mechanism of POCD are not clear. Neuroinflammation, brain mitochondrial dysfunction, cerebral embolism, ischemia, hypoxia, other factors related pathogenesis POCD. There close relationship between CPB POCD, as can cause inflammation, hypoxia reperfusion injury, microemboli formation, all which trigger increases medical costs, seriously affects patients' quality life, mortality. Currently, there lack effective treatment methods for Commonly include preoperative health management, reducing inflammation response during surgery, preventing implementing individualized rehabilitation programs Strengthening preventive measures minimize occurrence adverse effects.